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Previous issue date: 2013-05-10 / OBJECTIVE: Preeclampsia is a disease that can lead to a high maternal and infant morbidity. Worldwide, the incidence of this disease is highly variable and there is no data on this disorder in the Brazilian population. This study aimed at determining incidence and risk factors in the hypertensive disorders during pregnancy in a neighborhood of Natal, in addition to observing the evolution of these disorders one year and five years after delivery.
METHODS: Prospective cohort study to assess the outcome of pregnancies of 242 women who became pregnant between 2004-2007 in the neighborhood of Bom Pastor in the city of Natal, state of RN, Brazil. Five years after delivery, there was an active search of thirty-nine (39) women who became pregnant and had a hypertensive disorder during pregnancy and/or pr?-ecl?mpsia, out of the total of 242 participants in the initial study. We administered a structured questionnaire to obtain basic information about the current clinical situation of patients and occurrences of subsequent pregnancy and presence of hypertensive disorders during pregnancy. We also searched for information on the use of hypotensive drugs and contraceptives. The following characteristics were checked and recorded: a) current weight, b) blood pressure c) body mass index - BMI, and we collected biological samples (blood and urine) for measurement of biochemical parameters and evaluation of microalbumin?ria. Finally, we monitored the ambulatory blood pressure (ABP), which uses the method of automatic measurement of heart rate, systolic and diastolic blood pressure and an average of the two for the period of 24 hours.
RESULTS: Out of 218 women who completed the study, the incidence of hypertensive disorders was of 16.9% (37 out of 218), while the incidence of preeclampsia was 13.8% (30 of 218). Women with preeclampsia had a BMI (body mass index) averaged of 25.3 (? 4.8) while this ratio in normotensive women was of 23.5 (? 3.7), p = 0.02. The risk of preeclampsia rises with age (OR 1084 p = 0.0034) and with a family history of hypertension (OR 2.6 p = 0.01). The follow-up one year after delivery revealed that 50% of women with hypertensive disorders in pregnancy remained hypertensive. High BMI was also observed after 5 years of delivery.
CONCLUSIONS: an elevated BMI, age above 35 years and excessive weight gain during pregnancy were associated with hypertension in the long term in patients with prior preeclampsia. History of preeclampsia increases the risk of chronic hypertension / OBJETIVO: A pr?-ecl?mpsia ? uma doen?a que pode evoluir com alta morbimortalidde materno-fetal. No mundo, a incid?ncia dessa doen?a ? bastante vari?vel e s?o poucos os dados sobre esse dist?rbio na popula??o brasileira. Este trabalho objetivou determinar a incid?ncia e os fatores de risco envolvidos nos dist?rbios hipertensivos durante a gravidez, avaliando-se a popula??o de gestantes em um bairro de Natal. Al?m de observar a evolu??o da gravidez, avaliou-se o dano cardiovascular, um ano e cinco anos, ap?s a realiza??o do parto.
M?TODOS: Estudo prospectivo, tipo coorte, para avaliar as intercorr?ncias da gesta??o de 242 mulheres que engravidaram entre 2004-2007 no bairro do Bom Pastor, em Natal RN, Brasil. Um ano ap?s o parto avaliou-se 39 mulheres e decorridos cinco (5) anos do parto, foi realizada uma busca ativa dessas mulheres, que engravidaram e apresentaram o dist?rbio hipertensivo da gravidez e ou pr?-ecl?mpsia, perfazendo 16,11% do grupo inicial do estudo. Foi aplicado um question?rio estruturado para obten??o de informa??es b?sicas sobre a situa??o cl?nica atual das pacientes e ocorr?ncia de gesta??o posterior, avalia??o do ?ndice de massa corp?rea (IMC) e presen?a de intercorr?ncias e dist?rbio hipertensivo ap?s a gravidez. Foram levantadas informa??es sobre uso de medicamentos hipotensores e m?todos contraceptivos. Foram verificados e registrados: a) peso atual; b) press?o arterial e c) ?ndice de massa corp?rea IMC, e coletadas amostras biol?gicas (sangue e urina) para mensura??o de par?metros bioqu?micos e avalia??o da microalbumin?ria. Para a avalia??o da presen?a de hipertens?o foi feita a monitoriza??o ambulatorial da press?o arterial (MAPA), que utiliza o m?todo de medi??o autom?tica da frequ?ncia card?aca, press?o arterial sist?lica e diast?lica, al?m da m?dia das duas durante o per?odo de 24 horas.
RESULTADOS: De 218 mulheres que completaram o estudo a incid?ncia dos dist?rbios hipertensivos foi de 16,9% (37 de 218), enquanto a incid?ncia de pr?-ecl?mpsia foi de 13,8% (30 de 218). Mulheres com pr?-ecl?mpsia tiveram um IMC (?ndice de massa corp?rea) m?dio de 25,3 (? 4,8) enquanto que nas mulheres normotensas esse ?ndice foi de 23,5 (? 3,7), p=0,02. O risco de pr?-ecl?mpsia aumenta com a idade (OR 1.084 e p=0,0034) e com hist?rico familiar de hipertens?o (OR 2.6 p=0,01). O seguimento, um ano ap?s o parto, revelou que 50% das mulheres com dist?rbios hipertensivos na gravidez se mant?m hipertensas. IMC elevado tamb?m foi observado ap?s cinco (5) anos do parto.
CONCLUS?ES: IMC elevado, idade acima de 35 anos e excessivo ganho de peso durante a gravidez foram associados com hipertens?o em longo prazo, em pacientes com pr?-ecl?mpsia pr?via. Hist?ria de pr?-ecl?mpsia aumenta o risco de hipertens?o cr?nica a longo prazo
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13286 |
| Date | 10 May 2013 |
| Creators | Dantas, Edailna Maria de Melo |
| Contributors | CPF:70410798487, http://lattes.cnpq.br/7207146627442417, Costa, Iris do C?u Clara, CPF:14076152468, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4794938J9, Andrade, L?ra de Melo Barbosa, CPF:70407690425, http://lattes.cnpq.br/0327817672623352, Sousa, Anast?cio de Queiroz, CPF:05139066300, http://lattes.cnpq.br/0943719413944615, Carvalho, Maria Goretti Freire de, CPF:05601592420, http://lattes.cnpq.br/8934375314306198, Ara?jo, Ana Cristina Pinheiro Fernandes de |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias da Sa?de, UFRN, BR, Ci?ncias da Sa?de |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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