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Previous issue date: 2006-09-29 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The objective of this study was perform, by the streptoavidin-biotin technique, an immunohistochemical analysis of the E-cadherin and CD44v6 in 15 lower lip squamous cell carcinomas and 15 of tongue, with varied histologic gradation of malignidade, in order to establish a possible relation between the expression these proteins and the anatomical localization of the lesions, metastasis, as well as with the Bryne`s histolologic grading of malignancy system. It was not observed significant statistical association between the localization of the lesions and the malignancy score, however, had a significant correlation between the histologic parameters of malignancy gradation and the total score of malignancy, being that the parameter degree of keratinization presented the highest correlation (r = 0,844). Taking in consideration the anatomical localization of the lesions, it was not significant difference between the profile of expression and the amount of immunopositive cells for Ecaderina and CD44v6. To the metastasis variable, also it was not observed significant difference between the profile of expression and the amount of immunopositive cells for evaluated proteins. However, it was observed a statistical significant difference in relation to the scores of malignancy, being that the low score presented the highest values for the profile of expression and the amount of immunopositive cells for the E-caderina and the CD44v6. It was observed a statistically significant and negative correlation between the expression profile, the amount of E-cadherin and CD44v6 immunopositive cells and the total score of malignancy. Therefore, based in the results of this study, it was concluded that the expression of the immunohistochemical markers E-caderina and CD44v6 did not constitute histological indicator of aggressiveness for the patients with lower lip and tongue squamous cell carcinomas / Este trabalho teve como objetivo verificar, atrav?s da t?cnica da estreptoavidina-biotina, a express?o imuno-histoqu?mica das prote?nas E-caderina e CD44v6 em 15 esp?cimes de carcinoma epiderm?ide de l?bio inferior e 15 de l?ngua, com variada grada??o histol?gica de malignidade, a fim de estabelecer uma poss?vel rela??o entre a express?o das referidas prote?nas e a localiza??o anat?mica da les?o, met?stase, assim como com a grada??o histol?gica de malignidade proposta por Bryne (1998). A an?lise estat?stica demonstrou que n?o houve associa??o significativa entre a localiza??o da les?o e os escores de malignidade, entretanto, houve uma correla??o significativa entre os par?metros de grada??o histol?gica de malignidade e o escore total de malignidade, sendo que o par?metro grau de ceratiniza??o apresentou a maior correla??o (r = 0,844). Levando-se em considera??o a localiza??o anat?mica das les?es, n?o houve diferen?a significativa entre o padr?o de express?o e a quantidade de c?lulas imunopositivas para E-caderina e CD44v6. Em se tratando da vari?vel met?stase, tamb?m n?o houve diferen?a significativa entre o padr?o de express?o e a quantidade de c?lulas imunopositivas para as prote?nas avaliadas. Entretanto, ressalta-se que foi observada uma diferen?a estatisticamente significativa em rela??o aos escores de malignidade, sendo que o escore baixo apresentou os maiores valores para o padr?o de express?o e a quantidade de c?lulas imunopositivas para a E-caderina e o CD44v6. Uma correla??o estatisticamente significativa e negativa entre o padr?o de express?o e a quantidade de c?lulas imunopositivas para a E-caderina e o CD44v6 e o escore total de malignidade foi observada. Portanto, com base nestes resultados, conclui-se que a express?o dos marcadores imuno-histoqu?micos E-caderina e CD44v6 n?o constituiu fator indicativo de maior agressividade morfol?gica para os pacientes portadores de carcinomas epiderm?ides de l?bio inferior e de l?ngua
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17162 |
| Date | 29 September 2006 |
| Creators | Cruz, Maria Carmen Fontoura Nogueira da |
| Contributors | http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787928A2, Bastos, Eider Guimar?es, CPF:33093156300, http://lattes.cnpq.br/3285430538082061, Oliveira, M?rcio Campos, CPF:67676146534, http://lattes.cnpq.br/5703051980918880, Freitas, Roseana de Almeida, CPF:28444361453, http://lattes.cnpq.br/9512014003639405, Souza, L?lia Batista de, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787927Z7&dataRevisao=null, Pinto, Le?o Pereira |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Patologia Oral, UFRN, BR, Odontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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