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Previous issue date: 2012-12-12 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Hebb postulated that memory could be stored thanks to the synchronous
activity of many neurons, building a neural assembly. Knowing
of the importance of the hippocampal structure to the formation of
new explicit memories, we used electrophysiological recording of multiple
neurons to access the relevance of rate coding from neural firing
rates in comparison to the temporal coding of neural assemblies activity
in the consolidation of an aversive memory in rats. Animals were
trained at the discriminative avoidance task using a modified elevated
plus-maze. During experimental sessions, slow wave sleep periods
(SWS) were recorded. Our results show an increase in the identified
neural assemblies activity during post-training SWS, but not for the
neural firing rate. In summary, we demonstrate that for this particular
task, the relevant information needed for a proper memory consolidation
lies within the temporal patters of synchronized neural activity, not
in its firing rate / Hebb postulou que a mem?ria poderia ser armazenada gra?as a
atividade s?ncrona de v?rios neur?nios, formando um assembleia neural.
Sabendo da import?ncia da estrutura hipocampal para a forma??o
de novas mem?rias expl?citas, utilizamos o registro eletrofisiol?gico de
m?ltiplos neur?nios para investigar a relev?ncia da codifica??o de taxa
(rate coding) dos disparos neurais, comparada com a codifica??o temporal
(temporal coding) da atividade de assembleias, na consolida??o de
uma mem?ria aversiva de ratos. Os animais foram treinados na esquiva
discriminativa usando um labirinto em cruz elevado modificado. Durante
as sess?es experimentais foram registrados per?odos de sono de ondas
lentas (SOL). Nossos resultados indicam um aumento da atividade
das assembleias neuronais identificadas durante o SOL ap?s o treino na
tarefa, sendo que o mesmo n?o acontece com a taxa de disparo. Em resumo,
demonstramos que para essa tarefa em particular, a informa??o
relevante ? consolida??o adequada da mem?ria est? codificada nos padr?es
temporais de sincroniza??o da atividade neural e n?o em sua taxa
de disparo
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17229 |
| Date | 12 December 2012 |
| Creators | Lemos, Nelson Alessandretti de Mello |
| Contributors | CPF:50591797100, http://lattes.cnpq.br/0649912135067700, Ribeiro, Alessandra Mussi, CPF:26403824899, http://lattes.cnpq.br/7373640456805525, Pereira J?nior, Ant?nio, CPF:25715330297, http://lattes.cnpq.br/1402289786010170, Barbosa, Fl?vio Freitas, CPF:01202150470, http://lattes.cnpq.br/3611261597113820, Cota, Vinicius Rosa, CPF:03151319696, http://lattes.cnpq.br/6882402886706744, Ribeiro, Sidarta Tollendal Gomes |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Psicobiologia, UFRN, BR, Estudos de Comportamento; Psicologia Fisiol?gica |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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