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Previous issue date: 2014-08-28 / Neste trabalho, os medicamentos de refer?ncia, gen?rico e similar com os princ?pios ativos ?cido Acetil Salic?lico, Paracetamol, captopril, hidroclorotiazida e mebendazol foram adquiridos em farm?cias locais e estudados por Termogravimetria (TG) e Calorimetria Explorat?ria Diferencial (DSC). A decomposi??o t?rmica foi avaliada objetivando obter a partir do M?todo de Ozawa a energia de ativa??o, em atmosfera inerte (de nitrog?nio), utilizando tr?s raz?es de aquecimento distintas (5, 10 e 20 oC min-1). A formula??o farmac?utica do AAS de refer?ncia foi o ?nico que apresentou perfil termogravim?trico diferente dos demais (gen?rico e similar) indicando, provavelmente intera??o entre os excipientes e o princ?pio ativo. Foi observado no gr?fico do log da raz?o de aquecimento pelo inverso da temperatura que n?o houve linearidade dos dados, isto ?, n?o houve correla??o entre os percentuais de perda de massa e a energia de ativa??o envolvida na decomposi??o t?rmica da formula??o farmac?utica do AAS de refer?ncia. A an?lise por calorimetria explorat?ria diferencial foi realizada em atmosfera de nitrog?nio, com raz?o de aquecimento de 10?C min-1. Na an?lise destes mesmos medicamentos, os dados das curvas encontradas sobre o ponto de fus?o foram, exceto para a hidroclorotiazida, s?o condizentes com a literatura. A hidroclorotiazida apresentou um ponto de fus?o bastante inferior ao encontrado na literatura, o que pode ser justificado devido ? intera??o do princ?pio ativo com o excipiente lactose. No estudo da pureza, utilizando a equa??o de Van?t Hoff , os medicamentos de hidroclorotiazida de refer?ncia e mebendazol de refer?ncia, gen?rico e similar apresentaram teor de impureza acima do limite estabelecido nesta equa??o que deve ser superior a 2,5 % mol. / In this work, the reference drugs, generic and similar to the active ingredients acetylsalicylic
acid, paracetamol, captopril, hydrochlorothiazide and mebendazole were purchased from local
pharmacies and studied by thermogravimetry (TG) and Differential Scanning Calorimetry
(DSC). Thermal decomposition was assessed to obtain from the Ozawa method the activation
energy in inert atmosphere (nitrogen), using three different heating ratios (5, 10 and 20 o
C
min-1). The pharmaceutical formulation of the AAS reference was the one who presented
different from the others (generic and similar) Thermogravimetric profile indicating likely
interaction between the active ingredient and excipients. Was observed at the heating rate of
the inverse temperature that no linearity of the data, ie, there was no correlation between the
percentage of mass loss and the activation energy involved in the thermal decomposition of
the pharmaceutical formulation of the AAS reference log graph. The analysis by differential
scanning calorimetry was performed in nitrogen atmosphere with a heating rate of 10 ? C
min-1. In the analysis of these same drugs, the data curves found on the melting point were,
except for hydrochlorothiazide, are consistent with the literature. Hydrochlorothiazide
presented a melting point well below that found in the literature, which may be justified due
to the interaction of the active ingredient with the excipient lactose. In the study of purity,
using the Van't Hoff equation, the reference drugs hydrochlorothiazide and mebendazole
reference generic and showed similar impurity content below the limit established that this
equation must be greater than 2.5 mol%
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/19471 |
| Date | 28 August 2014 |
| Creators | Paula, Sueilha Ferreira de Andrade de |
| Contributors | 44420773472, http://lattes.cnpq.br/9563490368583906, Ara?jo, Eliane Gon?alves de, 03363541422, http://lattes.cnpq.br/4720265425355110, Moura, Maria de F?tima Vit?ria de, 31482015404, http://lattes.cnpq.br/2959800336802498, Ara?jo, Sulene Alves de, 51205645420, http://lattes.cnpq.br/2959800336802498, Fernandes, Nedja Suely |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM QU?MICA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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