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Previous issue date: 2016-10-04 / O hipocampo ? relacionado com a forma??o de mem?rias explicitas e com a capacidade
de reconhecer novos objetos. No presente trabalho visamos contribuir para uma maior
compreens?o do papel da regi?o CA1 do hipocampo nestes processos. Atrav?s da
aplica??o de t?cnicas de eletrofisiologia, comportamento animal, psicofarmacologia e
optogen?tica em camundongos transg?nicos e selvagens, encontramos que c?lulas
OLM?2 do CA1 atuam na codifica??o da representa??o de objetos em uma tarefa de
reconhecimento de objetos, e tamb?m influenciam a codifica??o de mem?rias aversivas
em uma tarefa associativa de medo ao contexto. Al?m disso, descrevemos uma nova
atividade oscilat?ria no potencial de campo local do CA1 na frequ?ncia beta 2 (23-30
Hz), que ? caracteristicamente transit?ria e ligada ? detec??o de novos objetos durante
uma tarefa de reconhecimento de objetos. Estes resultados sugerem potenciais
mecanismos celulares e de rede neuronal na regi?o CA1 subjacentes ao seu papel na
forma??o de mem?rias e na detec??o de novidade. / The hippocampus is associated to novelty detection and formation of explicit memories.
The present work aims at better understanding the role of the CA1 region of the
hippocampus in these processes. By employing electrophysiology, animal behavior,
psychopharmacology and optogenetic techniques in transgenic and wild-type mice, we
found that CA1 OLM?2 cells influence the formation of new object representations in an
object recognition task, as well as the encoding of aversive memories in a contextual fear
memory task. Furthermore, we characterized a new oscillatory activity in the local field
potential of CA1 at beta 2 frequency (23-30 Hz), which was typically transient and linked
to the amount of novelty in an object recognition task. These results suggest potential
cellular and network mechanisms that underlie the role of CA1 in memory formation and
novelty detection.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/22234 |
| Date | 04 October 2016 |
| Creators | Fran?a, Arthur S?rgio Cavalcanti de |
| Contributors | 96602767020, http://lattes.cnpq.br/3181888189086405, Laplagne, Diego Andres, 70638083460, http://lattes.cnpq.br/0293416967746987, Rossato, Janine Inez, 95279490091, http://lattes.cnpq.br/8136970112250481, Cunha, Cl?udio da, 26923637104, Barbosa, Fl?vio Freitas, 01202150470, http://lattes.cnpq.br/3611261597113820, Le?o, Richardson Naves, Tort, Adriano Bretanha Lopes |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM NEUROCI?NCIAS, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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