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Previous issue date: 2007 / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Introdução: Ha quase dez anos surgiram os primeiros relatos que o GBV-C, um novo virus RNA apatogenico, exerceria influencia sobre a infeccao pelo HIV, protelando a progressao para aids55, 56, 17, 19,20,59-63. Entretanto, muitos estudos nao chegaram a estes resultados57, 64-66. Maior ainda e a controversia na relacao entre o HIV, o HCV e GBV-C, quando em tripla infecca06O, 66,137,139-141,144. Objetivo: Estimar a prevalencia de marcadores de infeccao pelo GBV-C entre pacientes com infeccao pelo HIV e com co-infeccao HIV/HCV e comparar os grupos, procurando identificar impacto da infeccao pelo virus G. Metodos: Estudo observacional, transversal, com inclusao prospectiva de voluntarios, que passaram por entrevista, exame fisico e coleta de sangue para determinacao de carga viral do HIV, contagem CD4, AL T, AST, GGT, HCV RNA quantitativo, genotipagem HCV, anti-E2 e GBV-C RNA. A partir dos resultados dos marcadores para GBV-C, foram alocados em grupos e comparados. Resultados: Foram incluidos 60 voluntarios, 30 infectados somente pelo HIV e 30 co-infectados HIV/HCV. A prevalencia de infeccao pelo GBV-C entre pacientes HIV-positivos (20 por cento) tendeu a ser menor que a descrita na literatura, porem a prevalencia de tripla infeccao HIV/HCV/GBV-C (27 por cento) e semelhante a relatada. A presenca de marcadores para o GBV-C se associou a maior exposicao parenteral e ao aumento da AST, isolado em pacientes HIV-positivos e em conjunto com elevacao da AL T em pacientes co-infectados HIV/HCV. Exceto pelos achados ja descritos, nao identificamos impacto do GBV-C sobre a evolucao de pacientes infectados pelo HIV e co-infectados HIV-HCV. Conclusoes: O GBV-C pode estar sendo transmitido preferencialmente pela via parenteral em nosso meio. Os maiores niveis de AST observados em associacao com GBV-C talvez sejam resultantes da infeccao de outros tipos celulares por este virus. Os maiores niveis de ALT e AST relacionados com a infeccao pelo GBV-C em co-infectados HIV/HCV talvez seja traducao da infeccao simultanea dos hepatocitos por estes tres virus. O numero reduzido de voluntarios em cada grupo certamente prejudicou a analise estatistica / Introduction: It has been almost ten years since the first studies suggesting that a new RNA apathogenic virus called GBV-C could delay the progression of HIV infection into aids55, 56, 17, 19, 20, 59-63. However, many studies couldn’t find this relationship57, 64-66. And the controversy around the simultaneous infection by HIV, HCV e GBV-C is even greater60, 66, 137, 139-141, 144. Objectives: To estimate the prevalence of GBV-C markers among patients infected with HIV and co-infected with HIV and HCV and to compare the groups, searching for differences related with GBV-C infection. Methods: Observational and prospective study. Volunteers were interviewed, had a physical examination and blood samples tested for HIV viral load, CD4 count, ALT, AST, GGT, quantitative HCV RNA, HCV genotyping, anti-E2 and qualitative GBV-C RNA. Accordingly with the results, the volunteers were divided into groups and compared. Results: 60 volunteers were included, 30 infected only by HIV and 30 co-infected with HIV/HCV. The prevalence of GBV-C markers among HIV-positive volunteers (20%) occurred in a small frequency compared to results of previous studies, though the prevalence of triple infection HIV/HCV/GBV-C (27%) was similar to what is found in the literature. The presence of GBV-C was related with more frequent parenteral exposure, higher levels of AST in patients infected only with HIV and higher levels of AST associated with higher levels of ALT in coinfected HIV/HCV patients. Conclusions: In our setting, GBV-C preferencial route of transmission may be parenteral. The higher levels of AST observed when GBV-C markers are present, may reflect the infection of other cell types by this virus. The higher levels of ALT and AST related with GBV-C in co-infected patients may reflect the simultaneous infection of hepatocytes by these three viruses. The reduced number of volunteers may have foreclosed the statistical analysis / FAPESP: Projeto 05/57611-5 / BV UNIFESP: Teses e dissertações
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unifesp.br:11600/23407 |
| Date | January 2007 |
| Creators | Lanzara, Graziela de Almeida [UNIFESP] |
| Contributors | Universidade Federal de São Paulo (UNIFESP), Granato, Celso Francisco Hernandes [UNIFESP] |
| Publisher | Universidade Federal de São Paulo (UNIFESP) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | 118 p. |
| Source | reponame:Repositório Institucional da UNIFESP, instname:Universidade Federal de São Paulo, instacron:UNIFESP |
| Rights | info:eu-repo/semantics/openAccess |
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