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Previous issue date: 2013-03-25 / Introduction: Metabolic syndrome (MS) is a complex disorder represented by a set of cardiovascular risk factors. The physical exercise and changing eating habits play a central role in the treatment and prevention of this syndrome. Adopting a healthy lifestyle is strongly related to improved life quality and interfere positively in the control of cardiovascular risk factors. To assist the risk of individuals suffering general cardiovascular clinical events, the Framingham Heart Study (FHS) recently published an multivariate algorithm for risk factor to assess the overall risk of cardiovascular disease (CVD).
Objective: Evaluate the effect of lifestyle modification on the Framingham risk score in subjects diagnosed with metabolic syndrome.
Methods: Randomized clinical trial controlled blind. The volunteers were randomly divided into four groups: dietary intervention + placebo (IN), nutritional intervention + supplementation of omega-3 (fish oil 3g/day) (INS3), nutritional intervention + placebo + physical activity (INE) nutritional intervention and physical activity + + supplementation of omega-3 (INES3). Weight, waist circumference, blood pressure, lipid profile (TC, HDL-C, TG), glucose, insulin, smoking and age were collected to calculate the risk score, General Cardiovascular Risk Profile (GCRP), and check criteria for SM.
Results: The study included 70 subjects. In the evaluation scores between the pre and post intervention yielded significant value (p <0.001). There was obtained a reduction to intermediate risk in 25.7% of cases. After intervention, there was a significant reduction (p <0.01) the "cardiovascular age", this being more significant in groups IN (5.2%) and INE (5.3%). Analyzing the risk factors individually, it was observed that while the effect was significant (p <0.05) for all factors.
Conclusion: The change in lifestyle showed positive results in the treatment of MS. All groups behaved similarly proposed interventions without statistical difference, obtaining a reduction in the risk score. / Introdu??o: A S?ndrome Metab?lica (SM) ? um transtorno complexo representado por um conjunto de fatores de risco cardiovascular. A pr?tica de exerc?cio f?sico e mudan?a de h?bitos alimentares desempenham um papel central no tratamento e preven??o desta s?ndrome. A ado??o de um estilo de vida saud?vel esta fortemente relacionada ? melhora da qualidade de vida e interfere de forma positiva no controle dos fatores de risco cardiovascular. Para auxiliar na avalia??o do risco de indiv?duos sofrerem eventos cl?nicos cardiovasculares em geral, o Framingham Heart Study (FHS) recentemente, publicou um algoritmo de fator de risco multivariado para avaliar o risco geral de doen?as cardiovasculares (DCV). Objetivo: Avaliar o efeito da modifica??o do estilo de vida sobre o escore de risco de Framingham em indiv?duos com o diagn?stico de s?ndrome metab?lica. M?todo: Ensaio cl?nico randomizado, controlado, cegado. Os volunt?rios foram alocados aleatoriamente em quatro grupos: interven??o nutricional + placebo (IN), interven??o nutricional + suplementa??o de ?cidos graxos ?mega-3 (3g/dia de ?leo de peixe) (INS3), interven??o nutricional + atividade f?sica + placebo (INE) e interven??o nutricional + atividade f?sica + suplementa??o de ?cidos graxos ?mega-3 (INES3). Para o c?lculo do escore de risco General Cardiovascular Risk Profile (GCRP) e verifica??o dos crit?rios de SM foram coletados peso, circunfer?ncia abdominal, press?o arterial, perfil lip?dico (CT, HDL-c,TG), glicose, insulina, tabagismo e idade. Resultados: Participaram do estudo 70 indiv?duos. Na avalia??o do escore, entre situa??o pr? e p?s interven??o obteve-se valor significativo (p<0,001). Obteve-se uma redu??o para risco intermedi?rio em 25,7% dos indiv?duos. Ap?s a interven??o, observou-se uma redu??o significativa (p<0,01) da idade cardiovascular, sendo esta mais expressiva nos grupos IN (5,2%) e INE (5,3%). Analisando os fatores de risco individualmente, observou-se que o efeito tempo foi significativo (p<0,05) para todos os fatores. Conclus?o: A mudan?a de estilo de vida apresentou resultados positivos no tratamento da SM. Todos os grupos se portaram de forma similar as interven??es propostas sem diferirem entre si, obtendo uma redu??o do escore de risco.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/1728 |
| Date | 25 March 2013 |
| Creators | Soares, Thays Soliman |
| Contributors | Bodanese, Luiz Carlos |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de, PUCRS, BR, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 7620745074616285884, 500, 600, -8624664729441623247 |
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