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An Analysis of Survival Data when Hazards are not Proportional: Application to a Cancer Treatment Study

Indiana University-Purdue University Indianapolis (IUPUI) / The crossing of Kaplan-Meier survival curves presents a challenge when conducting survival analysis studies, making it unclear whether any of the study groups involved present any significant difference in survival. An approach involving the determination of maximum vertical distance between the curves is considered here as a method to assess whether a survival advantage exists between different groups of patients. The method is illustrated on a dataset containing survival times of patients treated with two cancer treatment regimes, one involving treatment by chemotherapy alone, and the other by treatment with both chemotherapy and radiotherapy.

Identiferoai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/27245
Date12 1900
CreatorsWhite, John Benjamin
ContributorsYiannoutsos, Constantin, Bakoyannis, Giorgos, Fadel, William
Source SetsIndiana University-Purdue University Indianapolis
Languageen_US
Detected LanguageEnglish
TypeThesis

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