Indiana University-Purdue University Indianapolis (IUPUI) / A pulsatile flow loop can be suitable for measurement of in vitro blood pressure. The
pressure data collected from such a system can be used for evaluating stenosis in human
arteries, a condition in which the arterial lumen size is reduced. The objective of this work
is to develop an experimental system to simulate blood flow in the human arterial system.
This system will measure the in vitro hemodynamics using 3-D prints of vessels extracted
from patient CT images. Images are segmented and processed to produce 3-D prints of vessel
geometry, which are mounted in the loop. Control of flow and pressure is made possible by
the use of components such as a pulsatile heart pump, resistance, and compliance elements.
Output data is evaluated by comparison with CFD and invasive measurement. The system
is capable of measurement of the pressures such as proximal, Pa, and distal, Pd, pressures
to evaluate in vivo conditions and to assess the severity of stenosis. This is determined by
use of parameters such as fractional flow reserve (FFR=Pd/Pa) or trans-stenotic pressure
gradient (TSPG=Pa-Pd). This can be done on a non-invasive, patient specific basis, to avoid
the risk and high cost of invasive measurement.
In its operation, the preliminary measurement of blood pressures demonstrates agreement
with the invasive measurement as well as the CFD results. These preliminary results are
encouraging and can be improved upon by continuing development of the experimental
system. A working pulsatile loop has been reached, an initial step taken for continued
development. This loop is capable of measuring the flow and pressure from in a 3-D printed
artery. Future works will include more life-like material for the artery prints, as well as
cadaver vessels.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/29164 |
| Date | 05 1900 |
| Creators | Talamantes, John, Jr. |
| Contributors | Yu, Huidan (Whitney), Chen, Jie, Zhu, Likun |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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