Master of Science / Department of Clinical Sciences / Gregory F. Grauer / Hyperthyroidism is the most common endocrinopathy of geriatric cats and has
physiologic effects on almost every organ in the body. It specifically affects the kidneys by
increasing renal blood flow and glomerular filtration rate. In addition, activation of the renin
angiotensin aldosterone system (RAAS) is increased and ultimately leads to efferent glomerular
arteriole constriction and potentially glomerular hypertension. The classic treatment modalities
for feline hyperthyroidism (anti-thyroid medication, radioiodine or surgery) have been evaluated
for their overall effects on renal function. Studies have demonstrated that glomerular filtration
rate (GFR) declines and serum creatinine increases with hyperthyroid treatment independent of
the treatment modality. Hill’s® Prescription Diet® y/d® Feline, a relatively new dietary treatment
modality for feline hyperthyroidism with controlled iodine concentrations, reduced phosphorus
and protein, and increased omega-3 fatty acids, has been shown to significantly decrease thyroid
hormone levels. The research provided in this report is the first evaluating the posttreatment
effects of y/d® Feline on renal function. In agreement with previous studies, our research found
that y/d® Feline resulted in a significant decrease in thyroid hormone levels. However, in
contrast to other treatment modalities, y/d® Feline did not result in a significant decline in GFR,
and it did result in a significant decline in mean serum creatinine concentration. These data
indicate that y/d® Feline, as a treatment for feline hyperthyroidism, does not have a negative
effect on renal function.
| Identifer | oai:union.ndltd.org:KSU/oai:krex.k-state.edu:2097/35273 |
| Date | January 1900 |
| Creators | Vaske, Heather |
| Publisher | Kansas State University |
| Source Sets | K-State Research Exchange |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
Page generated in 0.0023 seconds