Unlike the central nervous system, axonal regeneration does occur in the peripheral nervous system, however, despite this, functional recovery from nerve transection injury remains dismal. This has been attributed to factors intrinsic to the motor or sensory cell body and to elements in the local site of injury including nerve gaps, scar and a limited time frame in which supportive growth factors and extracellular matrix molecules are expressed. The aim of this thesis is to review the mechanisms behind axonal damage and regeneration in the peripheral nervous system and investigate surgical, pharmacological and biological approaches to overcome limitations in regeneration and functional recovery. By taking a broad approach to the topic, I hoped to gain a greater understanding of the inhibitory and regenerative processes at play and provide a contribution to the understanding in the field of peripheral nerve surgery. / Experimental Surgery
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:AEU.10048/595 |
| Date | 11 1900 |
| Creators | Ladak, Adil |
| Contributors | Tredget, Edward (Surgery), Gordon, Tessa (Neuroscience), Tredget, Edward (Surgery), Gordon, Tessa (Physical Medicine and Rehabilitation), Olson, Jaret (Surgery), Chan, Ming (Physical Medicine and Rehabilitation) |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 3981980 bytes, application/pdf |
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