Prostate cancer is the most common cancer among Canadian men. The standard treatment in high-risk category is radical radiation, with androgen suppression treatment (AST). Significant disease progression is reported despite this approach. Radiation dose escalation has been shown to improve disease-free survival; however, it results in higher toxicities. Hypofractionated radiation schedules (larger dose each fraction in shorter overall treatment time) are expected to deliver higher biological doses. A hypofractionated scheme was used in this study to escalate radiation doses with AST. Treatment was well tolerated acutely. Early results of self-administered quality of life reported by patients shows a decrease in QOL which is comparable to other treatment schedules. Significant positional variation of the prostate was observed during treatment. Therefore, we suggest daily target verification to avoid a target miss. Initial late effects are reasonable and early treatment outcomes are promising. Longer follow-up is required for full outcomes assessments.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:AEU.10048/699 |
| Date | 11 1900 |
| Creators | Pervez, Nadeem |
| Contributors | Murray, David (Oncology), Pearcey, Robert (Oncology), Mackenzie, Marc (Oncology), Shaw, Andrew (Oncology), Wu, Jackson (Oncology, University of Calgary) |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 4561278 bytes, application/pdf |
| Relation | Nadeem Pervez. Int J Radiat Oncol Biol Phys. 2009 Apr 21. [Epub ahead of print] Acute Toxicity in High-Risk Prostate Cancer Patients Treated with Androgen Suppression and Hypofractionated Intensity-Modulated Radiotherapy. |
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