This study used the non-alcoholic steatohepatitis activity index (NAI), presence of
fibrosis and Mallory-Denk bodies (MDBs), and quantification of glucose regulated
protein 78 (GRP78) messenger ribonucleic acid (mRNA) as indicators of steatohepatitis
development and recovery in the American mink (Neovison vison). Mink were fasted for
0, 1, 3, 5, or 7 days, and one group re-fed 28 days post 7-day fast. Liver NAI indicated
that moderate fatty liver developed after 5 days of fasting. Liver recovery was achieved
after the re-feeding period. There was no evidence of fibrosis or MDB formation. Upregulation
of GRP78 was observed by day 7 of fasting indicating endoplasmic reticulum
stress. This effect was greater in females. Results suggest that liver steatosis did not
advance to steatohepatitis within a 7-day fast. However, should the length of fast be
increased the mink may be at risk. Results also show that liver recovery from simple
fatty liver is possible.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:NSHD.ca#10222/14210 |
| Date | 04 August 2011 |
| Creators | Pal, Catherine |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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