Ovarian cancer and breast cancer share many of the same risk factors. The strongest known risk factor for breast cancer is mammographic density, the radiological appearance of breast tissue on a mammogram. Even though breast and ovarian cancer share many of the same risk factors, mammographic density has never been examined in relation to ovarian cancer. The present thesis describes a pilot study that was conducted to determine the feasibility of a study looking to address the issue of mammographic density as a risk factor for ovarian cancer. It was found that a larger study was feasible and should consist of approximately 700 case-control pairs recruited from cancer centres across Ontario, with cases matched to sisters or first-degree cousins. It was also found that the use of sister controls for cases did not lead to overmatching on mammographic density, and sisters are a suitable control group.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/18818 |
| Date | 15 February 2010 |
| Creators | Linton, Linda |
| Contributors | Boyd, Norman F. |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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