Purpose: To determine whether reduced serum levels of AHSG and elevated levels of BMP-2,
4, 7 are associated with post-arthroplasty HO. Patients: Thirty arthroplasty patients were
included, 15 with evidence of peri-articular HO and 15 without (NHO). Methods: Blood
samples were collected from all patients ≥ 8 weeks after arthroplasty. Analytes were measured
using ELISAs. Mann-Whitney U tests were performed to compare serum analyte concentrations
between HO and NHO groups, and between arthroplasty patients and healthy humans. Results:
There is no difference in serum concentrations of AHSG, BMP-2, 4, 7 between HO and NHO
patients. Arthroplasty patients showed significantly higher BMP-2 and BMP-4 and lower AHSG
serum levels compared to healthy humans (p < 0.01). Conclusion: Baseline BMP-2, 4, 7 and
AHSG serum levels are not markers of acquired HO. However, elevated baseline levels of BMP-
2, 4 and reduced levels of AHSG appear to be markers of severe inflammatory arthritis.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/25405 |
| Date | 14 December 2010 |
| Creators | Albilia, Jonathan |
| Contributors | Tenenbaum, Howard, Clokie, Cameron |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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