The hippocampus is a brain region that is critically involved in memory formation. Stratum oriens-lacunosum/moleculare (O-LM) interneurons have been shown to modulate incoming sensory information onto principal cells in CA1. Multi-compartment computational models of O-LM cells have been developed to better understand their functional roles in network contexts. Due to the variability and incompleteness of experimental details, however, a population of models that collectively captures intrinsic O-LM cell behavior is needed. We generated a database of O-LM models with physiologically plausible ranges for conductance densities using NEURON simulations on a supercomputer cluster. A subset of models that best represented O-LM cell electrophysiological output was subsequently extracted from the database and analyzed in order to determine correlations in conductance densities. Three major co-regulatory balances were found, which provide specific hypotheses for experimental investigations and point to the possibility of identifying a “signature” of conductance density balances for particular neuronal cell types.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/42913 |
| Date | 27 November 2013 |
| Creators | Sekulic, Vladislav |
| Contributors | Skinner, Frances |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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