The AAA ATPase p97/VCP functions in numerous cellular pathways. The molecular function of p97 in any of these pathways is specifically determined by the adaptor protein it is bound to. I am interested in studying new p97 functions, specifically their role related to cancer, such as apoptosis and cytoskeletal rearrangements. I initially focused on identifying the apoptotic adaptor of p97. I showed that PTEN is not the adaptor linking p97 to apoptosis through immunoprecipitation. Bioinformatics analysis revealed 14 potential p97 adaptors. FAF1 is the one involved in apoptosis, while Socius is a candidate for cytoskeletal rearrangements. I was able to outline a general strategy of how to determine and functionally classify candidate p97 interacting proteins.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.101739 |
| Date | January 2006 |
| Creators | Sabatier, Laetitia. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Anatomy and Cell Biology.) |
| Rights | © Laetitia Sabatier, 2006 |
| Relation | alephsysno: 002585663, proquestno: AAIMR32855, Theses scanned by UMI/ProQuest. |
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