Gonadotropic activity in human pregnancy urine was demonstrated for the first time by Aschheim and Zondek in 1927 by injecting unaltered urine into immature female rats. The early subsequent work was concerned mostly with gonadotropins secreted in large amounts by the human placenta. Pituitary gonadotropins, however, occur in much smaller amounts in human urine. They therefore must be concentrated from urine in order to be demonstrable by bioassay methods. The concentration of urinary extract, in turn, requires detoxification in order to allow the laboratory animals to survive several injections.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.111155 |
| Date | January 1957 |
| Creators | Freund, Gerhard. |
| Contributors | Venning, E. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Investigative Medicine) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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