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Effects of high protein consumption on bone and body composition from early to late adulthood in female rats

Long-term, high protein diets at 35% of energy may have implications in bone biology. The objective of this study was to comprehensively examine whether a high mixed protein diet at the 35% energy level can be deemed safe with respect to long-term bone health. Eighty female Sprague-Dawley rats were randomized to receive 4, 8, 12, or 17 months of a control (15% of energy as protein) or the high protein diet (35% of energy). Statistical analyses of biochemical, biomechanical, morphological, microarchitectural, and densitometric examinations using a 2-way factorial ANOVA with interaction revealed that elevated protein consumption had no negative consequences to bone health. High protein fed rats had increased lean body mass and decreased body weight and body fat. Thus preliminary results suggest that protein consumption at 35% of energy has a positive effect on body weight and does not hinder the mechanical abilities of bone.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.112347
Date January 2008
CreatorsPye, Kathleen.
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageMaster of Science (School of Dietetics and Human Nutrition.)
RightsAll items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.
Relationalephsysno: 002770371, proquestno: AAIMR51325, Theses scanned by UMI/ProQuest.

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