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Early biochemical alterations in rat liver following carbon tetrachloride intoxication.

Carbon tetrachloride (tetrachloromethane, CCl4) was discovered in 1839 by the French chemist and physician, H. V. Regnault, as a product of the action of chlorine upon chloroform in sunlight (1). It is almost insoluble in water, but is miscible with chloroform, alcohol, ether and benzene (1, 2, 3). Its non-flammability and low cost are the chief factors combining to make CC14 one of the most widely-used volatile solvents today. Hardin (1) has prepared an interesting review which traces the history of CC14 through its various applications and uses. For approximately 12 years (1865-67), CCl4 had a short and unhappy trial as an anaesthetic, and was proven to be inferior to chloroform in this capacity.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.113717
Date January 1962
CreatorsMaximchuk, Arlene. J.
ContributorsRubenstein, D. (Supervisor)
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageDoctor of Philosophy. (Department of Chemistry.)
RightsAll items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.
Relationalephsysno: NNNNNNNNN, Theses scanned by McGill Library.

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