Acetylcholine (ACh) is widely accepted as a neurotransmitter substance. The marked physiological activity of this substance could have been suspected from the early pharmacologic studies of Hunt and Taveau who demonstrated its intense depressor activity. Later, Ewins isolated it from specimens of ergot which had depressor action on organs supplied by autonomic nerves. Dale then found that this depressor activity was similar to that of muscarine-like substances and that this effect could be abolished by atropine. The same author also showed that ACh could easily be inactivated by an esterase present in tissue.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.113749 |
| Date | January 1962 |
| Creators | Proulx, Peter. |
| Contributors | Hosein, E. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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