Homovanillic acid has been shown by several investigators to be a constituent of normal human urine. In certain disease states, the urinary level of homovanillic acid is altered. This tact may be used as a criterion for clinical diagnosis of these diseases. Several method are available for measuring homovanillic acid, but they are relatively involved and costly procedures. The purpose of this study was to determine a rapid method which could be used routinely for the clinical measurement of homovanillic acid. Dopamine and its metabolite, 3, 4-dihydroxyphenylacetic acid, have been shown in Dr. Sourkes' laboratory to be abnormal in certain diseases. Another metabolite of these substances, homovanillic acid, has also been found in elevated amounts in some diseases.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115235 |
| Date | January 1963 |
| Creators | Sankoff, Irwin. |
| Contributors | Blackwood, A. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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