Investigations of the participation of non-endocrine organs in steroid transformations are gaining equal prominence with those studies in which end products of overall steroid metabolism are sought in the excretia. Although the liver probably plays an important role in this regard, the importance of extrahepatic tissues in steroid metabolism is becoming increasingly apparent. In 1948 Werthessen and collaborators (1, 2, 3) reported that incubation of estrone in blood resulted in destruction of the 17-keto function of the steroid accompanied by a loss of biological activity. On the other hand, Bischoff and associates (4, 5) incubated the red cells of rabbit or man with estrone and observed a marked increase in the biological activity of the added steroid. The discrepancy in the two sets of data was ascribed at the time to differences either in assay techniques or in experimental conditions.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115292 |
| Date | January 1963 |
| Creators | Trachewsky, Daniel. |
| Contributors | Hobkirk, R. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
Page generated in 0.0121 seconds