The suppression of the formation of corticosterone by the rat adrenal tissue in vivo and in vitro by androgens is reported. There is some evidence that androgens can be converted to more polar compounds by the incubated glands. Two such metabolites of 17α-methyl-Δ5-androstene-3β, 17β-diol (MAD) have been investigated. One is methyltestosterone, probably formed by the oxidation of MAD by the enzyme, 3β-hydroxydehydrogenase. The other may, in addition, contain one or more extra hydroxyl groups. Even more polar compounds have been observed. Whether these originate from the exogenous androgens or arise as a consequence of diversion of corticoid synthesis from corticosterone is not known.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115324 |
| Date | January 1963 |
| Creators | Young, Peter. C. |
| Contributors | Saffran, M. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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