The nephrotic syndrome bas been defined as a "pathological state of divergent etiologies, characterized by hyperlipemia, proteinuria, hypoalbuminemia and edema." (1) The primary site of the disease process is in the glomerulus and under the light microscope thickened, frayed glomerular basement membranes can be seen. (2)Electron microscopy on the other band, reveals that the lesion is chiefly due to an alteration of the epithelial layers of the basement membrane, there is a fusion or smudginess of the podocytes to form broad plaques of epithelial cytoplasm. Several etiological agents have been known to induce a nephrotic syndrome: systemic diseases such as diabetes mellitus, lupus erythematous, amyloidosis; infectious diseases, syphillis, malaria; chemical agents, trimethadione, paradione, gold salts, penicillamine; allergic reactions to bee stings, poison oak; renal diseases, chronic glomerulonephritis, acute poststreptococcal glomerulonephritis and renal vein thrombosis.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115368 |
| Date | January 1964 |
| Creators | Brown, Nydia. D. |
| Contributors | Kalant, N. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Biochemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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