Acetylcholine (ACh) was first synthesized by Bayer (1867), but its pharmacological action vas not realised until Hunt and Traveau (1906) illustrated its depressor activity on the nervous system, an action which could be abolished by atropine. Dixon (1906) noted that muscarine mimicked vagal stimulation and later restated the possibility of humoral mediation by chemicals (Dixon and Hamill, 1909), an idea first put forward by Elliott (1904) with regard to the possible mode of action of adrenalin. The first indication that ACh was a naturally occurring substance came with its isolation from some extracts of ergot which had been observed to have pressor effects (Ewins, 1914).
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115378 |
| Date | January 1964 |
| Creators | Chabrol, John. G. |
| Contributors | Hosein, G. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Biochemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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