A large number of 17-ketosteroids have been found in the urine since the first one vas isolated almost thirty-five years ago. Butenandt and his co-workers in 1931 (1) first isolated a crystalline steroid with androgenic activity from a chloroform extract of normal male urine which had been hydrolysed with acid and subsequently identified it as androsterone in 1934 (2). In the same year, these authors described the isolation of dehydroisoandrosterone from urine. (3) In 1938 Butler and Marrian (4) reported the isolation of two other 17-ketosteroids, etiocholanolone and isoandrosterone, from a large quantity of unhydrolysed urine excreted by a woman with an adrenocortical tumour. The isolation of etiocholanolone from the urine of a normal male subject was reported by Callow (5) in 1939.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115389 |
| Date | January 1964 |
| Creators | Clark, Albert. F. |
| Contributors | Solomon, S. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Biochemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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