The nucleoli of differentiating cells have long attracted the interest of investigators because of their variahility in number, volume and cytochemical features. Such variations have commonly been related to the physiochemical and cytochemical organization of the nucleolus. Specifically, the nucleolus has been considered an organelle of extreme plasticity, consisting of an apparently homogeneous ground substance (nucleolar matrix) which occasionally contains one or more vesicles (intranucleolar vacuoles or nucleolini). Relevant cytochemical and biochemical studies have indicated that these structural phases are composed of acid and basic proteins and RNA in the form of ribonucleoproteins. In brief, the classical concept of nucleolar structure recognized two intranucleolar structural phases -- nucleolar matrix and intranucleolar vacuoles -- composed of nucleolar ribonucleoproteins (reviews, Montgomery, 1898; Oates, 1942; Vincent, 1955; Stich, 1956; Hertl, 1957; Swift, 1959; Sirlin, 1962; Busch et al, 1963). [...]
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.118187 |
| Date | January 1965 |
| Creators | Shea, John R. |
| Contributors | Leblond, C. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosphy. (Department of Anatomy.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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