Miniaturized titanium implants placed in the diaphysis of mouse femurs were used as a model to examine concurrent effects on bone marrow lymphocytes, while attempting to accelerate the osseointegration of titanium implants by applying human recombinant Transforming Growth Factor Beta1 (TGF-beta 1) in carrier medium to the implant site, prior to implant placement. While the response of lymphocytes to titanium implants has been addressed, at present, the response of these cells in vivo to TGF-beta 1 remains unknown. The use of double immunofluorescence to bind molecular markers has allowed the detection of the various phenotypic stages during B cell differentiation, including both precursor B cells and early progenitor cells, as well as CD4-, and CD8- T cells, in femurs receiving 1mug, 10mug, and 100mug TGF-beta 1/100mul carrier medium, and carrier medium alone prior to implant placement. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.20840 |
| Date | January 1998 |
| Creators | Plyam, Raphael. |
| Contributors | Rahal, Dwayne (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Faculty of Dentistry) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001605554, proquestno: MQ44247, Theses scanned by UMI/ProQuest. |
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