Thalamotomy and pallidotomy constitute the two principal neurosurgical treatments for Parkinson's disease. Both the thalamus nuclei and the internal globus pallidus structures are found very close to the internal capsule, a critical structure that must be avoided in performing the lesion. This forces the lesion of parts of the thalamus and the globus pallidus mediale to be achieved with a spatial precision on the order of 2mm. The leukotome is a neurosurgical tool consisting of a 20cm rigid shaft with a thin metallic wire attached to its tip that can be taken in and out of the body of the shaft. It is used as a knife to perform the excision. / Some critical basal ganglia structures show no anatomical differences at all on MRI scans, even though they have different functionality. In order to provide the neurosurgeon with this missing information, we have developed a deformable volumetric atlas of the basal ganglions from the cryogenic slices atlas of Shaltenbrand and Wahren. The atlas can be non-linearly deformed to fit a patient's MRI. / We have developed a visualization platform for pre-operative and intra-operative utilization of the atlas and of the MRI datasets. Any number of datasets can be superimposed (MRI, atlases, virtual lesions...). Merging of datasets with different extents and different resolutions is supported. The platform includes 3D visualization tools as well. Graphical tools allow the neurosurgeon to see projections of the leukotome from any point of view over the MRI data and the atlas. The software is able to create models of lesions that can be compared with the MRI data and the atlas. It can also suggest an operation protocol (how to use the leukotome) if a target volume is given. This target volume can easily be drawn on the atlas by the neurosurgeon.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.20873 |
| Date | January 1997 |
| Creators | St-Jean, Philippe. |
| Contributors | Peters, Terence M. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Medical Radiation Physics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001604676, proquestno: MQ44289, Theses scanned by UMI/ProQuest. |
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