Transformed fatigue resistant skeletal muscle has been proposed as a potential power source for totally implantable ventricular assist systems (VAS). The goal of this study was to determine the optimal latissimus dorsi muscle (LDM) configuration capable of obtaining maximum power output. A device was designed to measure the power output and performance characteristics at varying levels of preload from each of four in situ configurations in Watts/kg of muscle(W/kg). Eight LDMs were acutely measured and revealed peak power output as follows: Sub-Dorsi (compliance chamber between LDM and chest wall): 8.3 +/- 1.6 W/kg; Circular (chamber in skeletal muscle ventricle): 16.4 +/- 6.2 W/kg; Linear-Origin (measurements from LDM thoracolumbar origin): 47.1 +/- 4.4 W/kg; Linear-Insertion (measurements from LDM humeral insertion): 59.9 +/- 12.1 W/kg, (ANOVA, p < 0.0001). A linear oriented LDM is capable of generating maximal power output comparable to current VAS requirements. Confirmation of these findings in mansformed, conformed, fatigue-resistant muscle will provide information essential for the optimal design of muscle powered ventricular assist systems.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.21508 |
| Date | January 1998 |
| Creators | Badhwar, Vinay. |
| Contributors | Chiu, Ray C-J. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001651145, proquestno: MQ50715, Theses scanned by UMI/ProQuest. |
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