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Temporal modulation of nephrotoxicity and of feeding and drinking by gentamicin treatment in rats

Gentamicin-induced nephrotoxicity varies temporally, with a peak being observed when this antibiotic is administered during the resting period and a trough when given during the activity period of rats. These variations are modified by fasting and by restricted feeding schedules. In this study, food and water intakes of adult female Sprague-Dawley rats were measured during pre-treatment (days 1 to 5) and during treatment (days 6 to 10) with gentamicin (80 mg/kg/day, i.p.) injected at 1300 h or 0100 h. A significantly higher level of serum creatinine was observed when gentamicin was administered at 1300 h compared to 0100 h, and a significantly lower creatinine clearance was found in rats treated with gentamicin at 1300 h compared to those treated with saline at the same time. Gentamicin treatment at 1300 h or 0100 h resulted in a decrease in the 24 h food intake. In addition, in the gentamicin-treated group at 0100 h, the maximal food intake observed at late dark during the pre-treatment period decreased during treatment, and early dark rather than late dark maximal intake occurred. Our data demonstrate that gentamicin induces a nephrotoxicity that varies temporally, and that gentamicin treatment inhibits food intake and alters its nocturnal variations.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.21576
Date January 1998
CreatorsJulien, Nancy.
ContributorsThibault, Louise (advisor)
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageMaster of Science (School of Dietetics and Human Nutrition.)
RightsAll items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.
Relationalephsysno: 001657801, proquestno: MQ50800, Theses scanned by UMI/ProQuest.

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