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Effects of dietary fatty acid composition and energy restriction on adipose tissue obese mRNA, fatty acid composition and serum leptin levels

Dietary fatty acid (FA) composition and energy restriction (ER) independently affect serum leptin levels; however it is not known whether this correlates with changes in obese (ob) gene expression. Herein, we assessed whether dietary FA composition and ER influence white adipose tissue (WAT) ob mRNA by Northern analysis. Animals consumed diets containing tallow (BT), safflower oil (SO) or fish oil (FO) ad libitum or at 60% ad libitum intakes. Serum leptin values were not different between levels of energy intake. ER decreased weight gain and WAT weights, which positively correlated with serum leptin values. WAT ob mRNA levels were in the rank order: FO > SO > BT in depots of all groups with ER showing a lower level of ob mRNA. Data show similarity in ob mRNA levels between depots with discordance in circulating leptin levels. These data suggest that energy restriction exerts greater control over leptin production than dietary fat source.
Date January 2002
CreatorsHynes, Geoffrey Ronald
ContributorsJones, J. H. (advisor)
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
CoverageMaster of Science (School of Dietetics and Human Nutrition.)
RightsAll items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.
Relationalephsysno: 001955784, proquestno: MQ85794, Theses scanned by UMI/ProQuest.

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