To investigate the relation between amniotic fluid (amf) constituents and human fetal growth and birth weight (b.wt), amf was collected from 395 pregnant women undergoing routine amniocentesis at 14--16 weeks' gestation at the Royal Victoria (RVH), Jewish General (JGH), and St. Mary's (SMH) Hospitals. The fluid was analyzed for total protein, albumin, urea nitrogen, creatinine, uric acid, glucose, beta-hydroxybutyrate (betaHBA), and lactate. Maternal and neonatal data were collected from a questionnaire at the time of recruitment and from medical charts post-delivery. The mean b.wt in our population was 3409 +/- 552g. Birth weight differed significantly by infant gender, maternal height (ht), and prepregnancy weight (wt), as determined by one-way analysis of variance (ANOVA). Of the amf constituents measured, glucose showed strong evidence of being a potential predictor of b.wt, such that for each mmol/L increase in amf glucose a 119.4g increase in b.wt was observed. Lactate showed a similar but weaker tendency toward predictive value. Ongoing research is currently being done to further examine the role of human amf constituents in predicting b.wt, the goal being to develop a predictive model that would aid in preparing for and preventing aberrations in fetal growth.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.29886 |
| Date | January 1999 |
| Creators | Elian, Kelly Marie. |
| Contributors | Koski, K. G. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (School of Dietetics and Human Nutrition.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001738007, proquestno: MQ55051, Theses scanned by UMI/ProQuest. |
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