Objectives. The prevalence of systemic lupus erythematosus (SLE) in Manitoba North American Indians (NAI) is hypothesized to be increased above that of Caucasians (CAUC), but little studied. To evaluate this we studied the prevalence rate of SLE in a population of 1.1 million. / Methods. The provincial arthritis center database and the medical records of all rheumatologists, hematologists, nephrologists, and general internists with ≥1 SLE patients were searched for cases of SLE diagnosed between 1980 and 1996. A subset of 175 medical records was reviewed for demographics, SLEDAI scores, SLICC/ACR damage indices, clinical manifestations and therapy. A random survey of 15% of family physicians serving this population suggested that >85% of all SLE cases were identified. / Conclusions. The prevalence of S:E was increased twofold in this NAI population. NAI patients had higher SLEDAI scores at diagnosis, more frequent vasculitis and renal involvement, required more treatment later in the disease course, accumulated more damage following diagnosis, and increased fatality. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.29919 |
| Date | January 1999 |
| Creators | Peschken, Christine A. |
| Contributors | Esdaile, J. (advisor), Joseph, L. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001681976, proquestno: MQ55086, Theses scanned by UMI/ProQuest. |
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