Objectives. (1) To measure the responsiveness of SLAM-R and SLEDAI to meaningful changes in SLE activity; (2) to determine how strongly activity in specific organ systems affects SLAM-R and SLEDAI responsiveness. / Methods. A secondary analysis was performed on blinded data of SLE patients. Sensitivity of SLAM-R and SLEDAI to change were assessed with traditional measures. Also, perceived change in disease activity was modelled as a function of change in overall instrument scores, and of change in organ system subscores. / Results. Both SLAM-R and SLEDAI were responsive to changes perceived by physicians. However, only SLAM-R was sensitive to changes reported by patients. The relevance of type of organ involvement depended on whether the assessor was the patient or the physician. / Conclusion. The differences between the type of change relevant to physicians and patients may account for SLAM-R's better ability to reflect patients' judgments.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.30810 |
| Date | January 2000 |
| Creators | Chang, Erika, 1976- |
| Contributors | Abrahamowicz, Michal (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001804649, proquestno: MQ70395, Theses scanned by UMI/ProQuest. |
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