This study sought to maximize prenatal and postnatal interventions in order to accelerate lung growth and improve lung function in two animal models. Prenatal interventions consisted of fetal tracheal occlusion (TO), antenatal glucocorticoids and exogenous surfactant at birth (SURF) in an ovine model of congenital diaphragmatic hernia (CDH). CDH, CDH+TO, CDH+SURF, CDH+TO+SURF and unoperated twin control lambs were compared. Prenatal growth of both lungs was accelerated after fetal TO. Prophylactic surfactant did not improve gas exchange or ventilation but did increase lung compliance over 8 hours. The incidence of tension pneumothoraces was slightly decreased after exogenous surfactant. Fetal TO yields the best results in terms of overall postnatal lung function, likely acting via surfactant independent mechanisms. / Postnatal intervention involved perfluorocarbon (PFC) liquid distention of the right upper lobe in healthy newborn piglets. Postnatal lung growth, as measured indirectly by rates of DNA synthesis, was not accelerated after PFC distention.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.33073 |
| Date | January 2001 |
| Creators | Butter, Andreana. |
| Contributors | Glageole, Helene (advisor), Laberge, Jean-Martin (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001838536, proquestno: MQ80111, Theses scanned by UMI/ProQuest. |
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