Early hypertrophy has justified the clinical use of vascularized bone grafts. This hypertrophy has not been established in experimental models, possibly because stress-shielded grafts were used. Our model allowed the grafts to bear weight. In 14 dogs we replaced the diaphysis of the radius with a vascularized fibula, and the diaphysis of the ulna with a conventional fibula (Group I). In 10 dogs we reversed the positions of the grafts (Group II). External fixation was used. The grafts were evaluated radiographically, mechanically and histologically. The vascularized grafts hypertrophied early, and were stronger than conventional grafts, particularly in Group I, where the former were stressed more. A previously unreported repair pattern was observed: vascularized grafts increased in size by peripheral apposition of new bone, there was no creeping substitution or weakening resorption. Conventional grafts remodeled by creeping repair, and hypertrophied slower, never reaching the size or the strength of the vascularized grafts.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.59599 |
| Date | January 1989 |
| Creators | Welter, Jean F. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001232489, proquestno: AAIMM63761, Theses scanned by UMI/ProQuest. |
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