The purpose of this study was to show that nifedipine, a calcium channel blocker, can decrease gallbladder contractility in guinea pigs and in man. Gallbladder contraction was measured in response to repeated injections of cholecystokinin both before and after the injection of nifedipine in three groups of five animals each. The mean amplitude of gallbladder contraction in response to cholecystokinin was decreased by 45, 73 and 67% (p $<$ 0.01) in response to intravenous nifedipine doses of 100, 200 and 300 $ mu$g respectively. In nine healthy human volunteers, gallbladder emptying was measured by radionuclide cholescintigraphy in response to cholecystokinin infusion before and after a 10 mg oral dose of nifedipine. Gallbladder ejection fraction was significantly decreased by 29% (p $<$ 0.001). These data demonstrate that nifedipine is a potent inhibitor of gallbladder contractility.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.60499 |
| Date | January 1991 |
| Creators | Clas, David |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001243391, proquestno: AAIMM72057, Theses scanned by UMI/ProQuest. |
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