The aim of this study was to examine apo(a)B particles distribution among plasma lipoproteins in two situations in which triglyceride-rich lipoproteins are increased: in normolipidemic subjects after a fat load and in patients with endogenous hypertriglyceridemia. / The results obtained demonstrate that, in hypertriglyceridemic patients, the distribution of apo(a)B particles among lipoprotein fractions is different than that observed in normotriglyceridemic subjects. These differences in distribution are a result of the association of apo(a)B particles with TG-rich lipoproteins. Contrary to apo(a)B particles found in the cholesterol-rich fraction apo(a)B particles in the TG-rich fraction are associated with lipoproteins of different sizes. The amount of apo(a)B particles in the TG-rich fraction could represent up to 50% of its total concentration and may contribute to the atherogenic and the thrombogenic potential of VLDL in HTG.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.60505 |
| Date | January 1991 |
| Creators | Selinger, Elizabeth |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Experimental Medicine.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001243314, proquestno: AAIMM72070, Theses scanned by UMI/ProQuest. |
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