The role of perivascular nerve fibers, smooth muscle cells and endothelium in the regulation of human and bovine cerebral artery contractility was investigated in vitro and the effect of cold-storage on vessel function was determined. Stimulation of perivascular nerve endings over a range of transmural electric field stimulation produced frequency- and duration-dependent responses in arteries of both species. The pharmacological properties of the cerebral vessels were studied using 17 different vasoactive agents which acted directly on the smooth muscle and/or on the endothelium. Parallel studies on human and bovine vessels indicate that the cow may be a very useful source of tissue for further experimentation. Cold-storage of cerebral arteries did not significantly alter vessel viability or responsiveness to vasoactive compounds, although a reduction in sensitivity to transmural electric field stimulation in human middle and posterior arteries was observed.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.60567 |
| Date | January 1991 |
| Creators | Kunicki, Suzanne |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pathology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001243455, proquestno: AAIMM72157, Theses scanned by UMI/ProQuest. |
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