The meniscus is essential for normal knee function. Previously considered unimportant, removal was performed when injured. This frequently led to degenerative arthritic changes. Today surgeons attempt to repair or minimally resect torn menisci, however many patients are encountered with irreparable tears or previously removed menisci. In these patients meniscale transplantation may prevent degenerative arthritis from developing. / Problems facing transplantation are ability to store tissues and prevent disease transmission. To overcome this, freezing and irradiation effects were examined on 60 rabbits undergoing medial meniscal transplantation. Fresh, frozen, and frozen-irradiated allografts were followed up to 17 months, 10 other rabbits underwent meniscectomy alone. / Zero-time studies revealed that freezing with or without irradiation rendered cells non-viable with no changes in mechanical properties. At long term follow-up, all grafts healed, and showed repopulation with metabolically active cells determined radioautographically. Mechanical properties were unchanged, except for a decreased time constant in the frozen group. Degenerative changes were not significantly different among groups.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.61219 |
| Date | January 1992 |
| Creators | Rubins, Ian Michael |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001277212, proquestno: AAIMM74919, Theses scanned by UMI/ProQuest. |
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