Dynamic cardiomyoplasty for hemodynamic support during acute pulmonary hypertension is studied. Five dogs underwent a right latissimus dorsi cardiomyoplasty. A graded acute pulmonary hypertension was later induced by infusion of glass microspheres into the pulmonary artery. A decrease in pulmonary artery flow, systemic pressure and systemic flow resulted. At an optimal level of hemodynamic impairment, the dynamic cardiomyoplasty was able to acutely improve pulmonary artery flow 26.4 $+/-$ 5.84% (SEM) (p $<$ 0.005), mean systemic arterial pressure 11.6 $+/-$ 3.7% (p $<$ 0.05), and the thoracic aorta flow 15.7 $+/-$ 6.3% (p $<$ 0.05). There was a significant beneficial hemodynamic effect demonstrated by dynamic cardiomyoplasty. The degree of improvement in hemodynamic variables could be correlated with the magnitude of hemodynamic impairment present. Dynamic cardiomyoplasty may be useful in patients with right heart failure associated with increased pulmonary vascular resistance.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.61332 |
| Date | January 1992 |
| Creators | Hill, Andrew Beverly |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001307472, proquestno: AAIMM80351, Theses scanned by UMI/ProQuest. |
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