The work reported here was aimed at extending previous findings suggesting that the medial and lateral substantia nigra (SN) are functionally different with regard to intracranial self-stimulation (ICSS) and circling. It was found that the effects of systemic D- and L-amphetamine on ICSS were different for medial and lateral SN sites. These differences were attributed to the presence of two subtypes of dopamine (DA) neurons in the SN. The circling results indicate that circling in opposite directions can be elicited from the medial and lateral parts of the nigrostriatal DA system from the same hemisphere suggesting that medial and lateral nigrostriatal DA have opposing roles in the expression of circling. It was further demonstrated that the superior colliculus is critical for the expression of medial SN derived circling and the midbrain reticular formation is critical for both medial and lateral SN derived circling.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.71895 |
| Date | January 1983 |
| Creators | Vaccarino, Franco. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Psychology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000186404, proquestno: AAINK66633, Theses scanned by UMI/ProQuest. |
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