A route to the synthesis of arabino and xylonucleosides is described. This route takes advantage of highly selective ribonucleoside hydroxyl protection procedures which have recently been developed. The route is straightforward and broadly applicable. It may be applied to both purine and pyrimidine nucleosides. Synthesis, deprotection, and characterisation of the target compounds are described. The work is compared to that of others in the field. / A novel class of oligonucleotide analogues is described. In this group, the phosphorus atom of the internucleotide link is replaced by silicon. The synthesis of both oligothymidine and oligo-2$ sp prime$-deoxyadenosine nucleotide analogues of this class is described. Various substituents at silicon are employed, and oligonucleotide analogs of up to six units long are synthesised, characterised and deprotected. The circular dichroism spectra of the deprotected hexamers is presented.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.75458 |
| Date | January 1987 |
| Creators | Cormier, James |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000554084, proquestno: AAINL44467, Theses scanned by UMI/ProQuest. |
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