Intra-abdominal infections are a common entity faced by general surgeons, which, when complicated by pneumonia lead to increased mortality. The susceptibility to a second infection is correlated with impaired polymorphonuclear neutrophil (PMN) migration to the remote site, perhaps due to inadequate PMN number. We tested the second front hypothesis that the elevated mortality arising from a second infection is due to insufficient circulating PMN, the majority being sequestered at the first site of infection. Further, augmentation of systemic PMN number by granulocyte colony stimulating factor (G-CSF) will decrease mortality. / We established a murine model for peritonitis and pneumonia. PMN counts in the blood, lung tissue, peritoneal cavity and bronchoalveolar system were measured. The results indicated significant PMN recruitment to the primary site of infection, whether lung or abdomen. Almost no PMN were found in the lung if it was the second site of infection. This was consistent with the second front hypothesis.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.78382 |
| Date | January 2003 |
| Creators | Huang, Felicia, 1970- |
| Contributors | Christou, N. V. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001975834, proquestno: AAIMQ88217, Theses scanned by UMI/ProQuest. |
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