Sutural distraction osteogenesis (SDO) has been proposed as a novel approach for cleft palate closure in an effort to avoid the shortcomings of traditional surgical repair. In this thesis, we present data that confirms that attempted distraction of the palatomaxillary suture (PMS) achieves cleft closure preferentially by alveolar arch collapse, and not by intended SDO. To that end, we have designed a novel custom-fit intraoral splint that successfully prevents maxillary collapse while facilitating cleft defect approximation via sutural distraction. Preservation of maxillary dimensions was confirmed via intraoral measurements and craniometrics. New bone deposition secondary to SDO was quantified with histomorphometry and microCT, while the effects of distraction on the PMS and palatal bone were assessed with histology and Dual-energy Xray Absorptiometry (DXA). In summary, approximation of palatal defects via SDO in a canine model without maxillary collapse is possible, and may be a promising therapeutic approach for the repair of cleft palates in human infants.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.84034 |
| Date | January 2005 |
| Creators | Gilardino, Miroslav S. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002262089, proquestno: AAIMR22726, Theses scanned by UMI/ProQuest. |
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