Normal bone marrow is composed of hematopoietic and non-hematopoietic cells. The later have also been termed stromal cells or mesenchymal cells. These cells were originally thought to provide an appropriate matrix for hematopoietic cell development, but recent examination of these cell populations suggests a much broader spectrum of activity, including the generation of bone, cartilage, tendon, fat and muscles including myocardium. / Cellular cardiomyoplasty (CCM) based on adult bone marrow stromal cells (MSCs) is a novel means of augmenting cardiomyocyte number and contractile function of the failing heart targeting the basic pathophysiology of heart failure. / Chapter I of this thesis briefly reviews the therapy of congestive heart failure and cellular cardiomyoplasty based on MSCs. The concept of MSCs for cardiomyoplasty and previous work conducted in our laboratory will be reviewed. Chapter II focuses on the fate of systemically implanted MSCs, in order to examine whether MSCs may participate in myocardial growth and injury in the post-natal immature hearts. / With the purpose of searching for universal donors for clinical application of MSC cardiomyoplasty, in chapter III we use a vast histocompatibility mismatch pig-to-rat model to examine the unique immune tolerance of MSCs. Chapter IV consists of closing remarks.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.84055 |
| Date | January 2005 |
| Creators | Luo, Jun, 1969- |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002261972, proquestno: AAIMR22747, Theses scanned by UMI/ProQuest. |
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