The perioperative use of cardiac medical therapy (aspirin, angiotensin-converting-enzyme (ACE) inhibitors, lipid lowering agents (including statins), and beta-blockers) holds the potential to improve clinical outcomes among patients undergoing coronary artery bypass graft surgery (CABG). These medications have been shown to be efficacious in reducing adverse events in a small number of trials involving non-cardiac surgery patients. However, their use has not been closely examined among CABG patients. We performed a systematic review of the literature in which we identified all studies that examined the perioperative use of cardiac medical therapy among CABG patients. We also examined the use and effectiveness of these medications using a cohort of 2,389 consecutive CABG patients. We found that in-hospital medication use was low for all 4 medication classes. We also found a trend indicating an association between perioperative beta-blocker and statin use and a decrease in in-hospital mortality or non-fatal cardiac complications. Increasing perioperative cardiac medical therapy use may therefore lead to improved clinical outcomes among patients undergoing CABG.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.97952 |
| Date | January 2005 |
| Creators | Filion, Kristian B., 1980- |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | © Kristian B. Filion, 2005 |
| Relation | alephsysno: 002332559, proquestno: AAIMR24667, Theses scanned by UMI/ProQuest. |
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