Ultrasonography is widely used in medical diagnosis with the advantages of being low cost, non-invasive and capable of real time imaging. When interpreting ultrasonographic images of mammalian ovaries, the structures of interest are follicles, corpora lutea (CL) and stroma. This thesis presents an approach to perform CL texture analysis, including detection and segmentation, based on the classiers trained by genetic
programming (GP). The objective of CL detection is to determine whether there is a CL in the ovarian images, while the goal of segmentation is to localize the CL within the image.
Genetic programming (GP) oers a solution through the evolution of computer programs by methods inspired by the mechanisms of natural selection. Herein, we use rotationally invariant local binary patterns (LBP) to encode the local texture features. These are used by the programs which are manipulated by GP to
obtain highly t CL classiers. Grayscale standardization was performed on all images in our data set based on the reference grayscale in each image. CL classication programs were evolved by genetic programming and tested on ultrasonographic images of ovaries. On the bovine dataset, our CL detection algorithm is reliable and robust. The detection algorithm correctly determined the presence or absence of a CL in 93.3% of 60
test images. The segmentation algorithm achieved a mean ( standard deviation) sensitivity and specicity of 0.87 (0.14) and 0.91 (0.05), respectively, over the 30 CL images. Our CL segmentation algorithm is an improvement over the only previously published algorithm, since our method is fully automatic and does not require the placement of an initial contour. The success of these algorithms demonstrates that similar algorithms designed for analysis of in vivo human ovaries are likely viable.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:SSU.etd-08102011-153450 |
| Date | 16 August 2011 |
| Creators | Dong, Meng |
| Contributors | Pierson, Roger A., Eramian, Mark G., Sarty, Gordon E., Ludwig, Simone |
| Publisher | University of Saskatchewan |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://library.usask.ca/theses/available/etd-08102011-153450/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Saskatchewan or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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